Publications

ʇPui Pik Law, ʇLiudmila A Mikheeva, ʇFrancisco Rodriguez-Algarra, Fredrika Asenius, Maria Gregori, Robert AE Seaborne, Selin Yildizoglu, James RC Miller, Hemanth Tummala, Robin Mesnage, Michael N Antoniou, Weilong Li, Qihua Tan, Sara L Hillman, Vardhman K Rakyan, David J Williams, Michelle L Holland (2024) Nat Commun 15:5006 Ribosomal DNA copy number is associated with body mass in humans and other mammals

Holland ML, Rakyan VK (2022) Nat Metab 4:1091 A stochastic basis of metabolic phenotypes

ʇRodriguez-Algarra F, ʇSeaborne RAE, Danson AF, Yildizoglu S, Yoshikawa H, Law PP, Ahmad Z, Maudsley VA, Brew A, Holmes N, Ochoa M, Hodgkinson A, Marzi SJ, Pradeepa MM, Loose M, Holland ML*, Rakyan VK* (2022) Genome Biol. 23:54 Genetic variation at mouse and human ribosomal DNA influences associated epigenetic states

Darya Deen, Falk Butter, Deborah E. Daniels, Ivan Ferrer-Vicens, Daniel C.J. Ferguson, Michelle L. Holland, Vasiliki Samara, Jacqueline A. Sloane-Stanley, Helena Ayyub, Matthias Mann, Jan Frayne, David Garrick, Douglas Vernimmen (2021) Blood Adv 5(15):3002-3015 Identification of the transcription factor MAZ as a regulator of erythropoiesis

Fredrika Åsenius, Tyler J. Gorrie-Stone, Ama Brew, Yasmin Panchbaya, Elizabeth Williamson, Leonard C. Schalkwyk, Vardhman K. Rakyan, Michelle L. Holland, Sarah J. Marzi, David J. Williams (2020) PLOS Genetics 16(10):e1009035 DNA methylation covariation in human whole blood and sperm: implications for studies of intergenerational epigenetic effects

Law P-P, Holland ML (2019) Essays Biochem 63: 717 DNA methylation at the crossroads of gene environment interactions

Law P-P, Holland ML (2018) Nutrients 10:1831 Deciphering the role of the non-coding genome in gene-diet interactions

Danson AF, Marzi SJ, Lowe R, Holland ML, Rakyan VK (2018) BMC Biol 16:51 Early life diet conditions the molecular response to post-weaning protein restriction in the mouse

Holland ML (2017) Ebiomedicine 17:3-4 Epigenetic regulation of the protein translation machinery

Holland ML, Lowe R, Caton PW, Gemma C, Carbajosa G, Danson AF, Carpenter AAM, Loche E, Ozanne SE, Rakyan VK (2016) Science 10.1126/science.aaf7040 Early life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice

Lowe R, Gemma C, Rakyan VK, Holland ML (2015) BMC Genomics 16:295 Sexually dimorphic gene expression arises with embryonic genome activation and is dynamic throughout development

Gemma C, Ramagopalan SV, Down TA. Beyam H, Hawa MI, Holland ML, Hurd PJ, Giovannoni G, Leslie RD, Ebers GC, Rakyan VK (2013) Genome Biol 14:R43 Inactive or moderately active promoters are enriched for inter-individual epialleles

Caton PW, Richardson SJ, Kieswich J, Bugliani M, Holland ML, Marchetti P, Morgan NG, Yaqoob MM, Holness MH, Sudgen MC (2013) Diabetologia 56:1068 Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetes patients

Holland ML, Rakyan (2013) Biochem Soc Trans 41:769 Transgenerational inheritance of non-genetically determined phenotypes

Beyan H, Down TA, Ramagopalan SV, Uvebrandt K, Nilsson A, Holland ML, Genmma C, Giovannoni G, Boehm BO, Ebers GC. Lernmark A, Cilio CM, Leslie RD, Rakyan VK (2012) Genome Res 22: 2138 Guthrie card methylomics identified temporally stable epialleles that are present at birth in humans

Proudhon C, Duffie R, Ajjan S, Cowley M, Iranzo J, Carbajosa G, Saadeh H, Holland ML, Oakey RJ, Rakyan VK, Schulz R, Bourc’his D (2012) Mol Cell 47:909 Protection against de novo methylation is instrumental in maintaining parent-of-origin methylation inherited from the gametes

Llamas B*, Holland ML*, Chen K, Cropley JE, Cooper A, Suter CM (2012) PLoS One 7:e30226 High-resolution analysis of cytosine methylation in ancient DNA

Arnold JC, Hone P, Holland ML, Allen JD (2012) Pharmacol Rep 64:751 CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells

Finer S*, Holland ML*, Nanty L, Rakyan VK (2011) Environ Mol Mutagen 52:1 The hunt for the epiallele

Holland ML, Allen JD, Arnold JC (2008) Eur J Pharmaocol 591:128 Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1)

Garrick D, De Gobbi M, Samara V, Rugless M, Holland ML, Ayyab H, Lower K, Sloane-Stanley J, Gray N, Koch C, Dunham I, Higgs DR (2008) Blood 112:3889 The role of the polycomb complex in silencing alpha-globin gene expression in nonerythroid cells

Garrick D, Samara V, Holland ML, Rugless M, Sloane-Stanley J, Gray N, Higgs DR (2007) Blood Cell Mol Dis 38:141 The role for both histone deacetylases and the PRC2 polycomb complex in repressing alpha-globin gene expression in non-erythroid tissues

Holland ML, Lau DT, Allen JD, Arnold JC (2007) Br J Pharmacol 152:815 The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids

Holland ML, Panetta JA, Hoskins JM, Bebawy M, Roufougalis BD, Allen JD, Arnold KC (2006) Biochem Pharmacol 71:1146 The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells